MoA Approved 29 Toxicological Labs for ICAMA Registration  

MOA CHINAThe MoA published the Announcement No 1876 on 19 Dec 2012 and granted the qualification to 29 testing facilities for pesticide registration. The 29 testing institutions are allowed to conduct toxicological studies for ICAMA registration in the next five years. Among the 29 qualified facilities, 6 of them have been entitled as the “GLP- Compliant” facilities (see table 1).

Table 1 List of the MoA-approved toxicological testing institutions [2012 MoA Announcement 1876]

No.

Chinese Name

English Name

Qualification type

Certificate No

[English Indication]

Note

1

中国疾病预防控制中心职业卫生与中毒控制所

National institute of Occupational health and Poison control, Chinese Center for Disease Control and Prevention

A

毒理-001

[toxicology-001]

 

2

中国人民解放军军事医学科学院毒物药物研究所

Institute of Pharmacology & Toxicology, Academy of Military Medical Sciences of the Chinese PLA

A

毒理-002

[toxicology-002]

GLP-compliant

3

北京协和建昊医药技术开发有限责任公司

Beijing Concorde Jianhao Pharmaceutical Technology Drug R&D Co., Ltd

A

毒理-003

[toxicology-003]

GLP-compliant

4

北京市疾病预防控制中心

Beijing Disease Control and Prevention Center

B

毒理-004

[toxicology-004]

 

5

中国人民解放军疾病预防控制所

Disease Control and Prevention Center of the PLA

B

毒理-005

[toxicology-005]

GLP-compliant

6

天津市疾病预防控制中心

Tianjin Disease Control and Prevention Center

A

毒理-006

[toxicology-006]

 

7

河北省疾病预防控制中心(河北省卫生检测中心)

Hebei Disease Control and Prevention Center(Hygiene Inspection Center)

B

毒理-007

[toxicology-007]

 

8

沈阳化工研究院安全评价中心

Safety evaluation Center, Shenyang Research Institute of Chemical Industry

A

毒理-008 [toxicology-008]

 

9

上海市预防医学研究院

Shanghai Disease Control center

A

毒理-009

[toxicology-009]

 

10

上海化工研究院检测中心

Shanghai Research Institute of Chemical Industry Testing Center

C

毒理-010

[toxicology-010]

GLP-compliant

11

江苏省疾病预防控制中心

Jiangsu Disease Control and Prevention Center

B

毒理-011

[toxicology-011]

 

12

南京医科大学卫生分析检测中心

Hygiene Analysis Inspection Center, Nanjing Medical University

B

毒理-012

[toxicology-012]

 

13

苏州西山中科药物开发有限公司

Suzhou Xishan Zhongke Drug R&D Co., Ltd

B

毒理-013

[toxicology-013]

GLP-compliant

14

南通通大化学物安全性评价中心有限公司

 Nantong University Chemical Safety evaluation Center Co., Ltd

C

毒理-014

[toxicology-014]

 

15

浙江长三角化学品安全评价有限公司

Chemical Safety evaluation Center of Zhejiang Yangtze River Delta Co., Ltd

B

毒理-015

[toxicology-015]

GLP-compliant

(Type C)

16

浙江省医学科学院

Zhejiang Academy of Medical Sciences

C

毒理-016

[toxicology-016]

 

17

安徽省疾病预防控制中心

Anhui Disease Control and Prevention Center

C

毒理-017

[toxicology-017]

 

18

福建省疾病预防控制中心

Fujian Disease Control and Prevention Center

C

毒理-018

[toxicology-018]

 

19

江西省职业病防治研究院

Jiangxi Occupational Disease Control and Prevention Center

B

毒理-019

[toxicology-019]

 

20

山东省职业卫生与职业病防治研究院

Shandong Research Institute of Occupational health and Diseases Control

C

毒理-020

[toxicology-020]

 

21

郑州大学公共卫生学院

Public Health Institute of Zhengzhou University

C

毒理-021

[toxicology-021]

 

22

湖北省疾病预防控制中心

Hubei Disease Control and Prevention Center

A

毒理-022

[toxicology-022]

 

23

华中科技大学同济医学院农药毒理研究中心

pesticide toxicology Research Center of Tongji Medical College, Huazhong University of Science and Technology

A

毒理-023

[toxicology-023]

 

24

湖南省职业病防治院

Hunan Disease Control and Prevention Center

B

毒理-024

[toxicology-024]

 

25

广东省职业卫生检测中心

Guangdong Ocupational Health

A

毒理-025

[toxicology-025]

 

26

广西壮族自治区职业病防治研究院

Guangdong Institute of Occupational health and Diseases Control

C

毒理-026

[toxicology-026]

 

27

四川大学华西公共卫生学院分析测试中心

Analysis Center of Public health Institute, Sichuan University

C

毒理-027

[toxicology-027]

 

28

贵阳医学院毒性检测中心

Toxicity Analysis Center of Guiyang Medical College

B

毒理-028

[toxicology-028]

 

29

新疆维吾尔自治区疾病预防控制中心

Xinjiang Uygur Disease Control and Prevention Center

C

毒理-029

[toxicology-029]

 

The testing facilities for agrochemicals are multi-channel administrated in China. They should either comply with the Measures for testing facilities of pesticide registration or the Chinese GLP rules. Under the “Measures for Toxicology Testing Facilities of Pesticide Registration”, the qualified facilities are further classified into three categories, Type A, Type B and Type C. Different types of facilities are allowed to carry out different studies (see Table 2).

Table 2.List of applicable test items and qualification Types

Test Item

Qualification Type

Type A

Type B

Type C

Part I

  • Acute Oral Toxicity Study;
  • Acute Dermal Toxicity Study;
  • Acute Inhalation Toxicity Study;
  • Skin irritation Study;
  • Eye irritation Study;
  • Skin Sensitization Study;

Part II

  • Ames Study on Mice ;
  • Micronucleus Study in Mammalian Bone Marrow Cell;
  • Chromosome Aberration Study in Mammalian Bone Marrow Cells;
  • Dominant Lethal Test on mammals;
  • Chromosome Aberration Study in Mammalian Generative Cells;
  • In Vitro Chromosome Aberration Study in Mammalian Cells;
  • In Vitro Gene Mutation Study in Mammalian Cells;
  • Pathogenic Test of microbial pesticide;
  • Sub-Acute Dermal Toxicity Study;
  • Sub-Acute Inhalation Toxicity Study;
  • Sub-Acute Oral Toxicity Study;

 

Part III

  • Genotoxicity Study;
  • Two Generation Reproductive Study;
  • Delayed Neurotoxicity Study;
  • Chronic Toxic Study;
  • Carcinogenicity Study;
  • Combined chronic toxicity/carcinogenicity Study;
  • Toxicokinetic Study;

 

 

 

Reference Link

MoA’s Announcement No 1876(in Chinese)

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