China Renews Toxicological Testing Methods for Pesticide Registration

On 12 Jul 2017, the Standardization Administration of China (SAC) issued Announcement 18 of 2017 to promulgate 28 toxicological testing methods for pesticide registration, which will take effect as of 1 Feb 2018 and replace the GB 15670-1995.

As the current and mandatory testing guideline, GB 15760-1995 consists of 23 methods covering six key criteria including acute toxicity, sub-acute toxicity, sub-chronic toxicity and mutagenicity, etc. In this update, 5 more methods are included:

Acute oral toxicity test—Up-and-down-procedure;
In vitro mammalian cells chromosome aberration test;
In vitro mammalian cell gene mutation test;
Unscheduled DNA synthesis (UDS) test with mammalian liver cells in vivo;
DNA damage and repair/unscheduled DNA synthesis in mammalian cells in vitro;

Together with the first chapter, the methods were released in a separate national standard under the GB 15760-2017 series. The code, Chinese and English name and alternation information are as follows:

Code	Title	Alternation Status
GB/T 15670.1-2017	Toxicological test methods for pesticides registration—Part 1: General principles 农药登记毒理学试验方法第1部分：总则
GB/T 15670.2-2017	Toxicological test methods for pesticides registration—Part 2: Acute oral toxicity test—Horn’s method 农药登记毒理学试验方法第2部分：急性经口毒性试验霍恩氏法	Partially replace GB 15670-1995
GB/T 15670.3-2017	Toxicological test methods for pesticides registration—Part 3: Acute oral toxicity test—Up-and-down-procedure 农药登记毒理学试验方法第3部分：急性经口毒性试验序贯法
GB/T 15670.4-2017	Toxicological test methods for pesticides registration—Part 4: Acute oral toxicity test—Miller and Taninter's method 农药登记毒理学试验方法第4部分：急性经口毒性试验概率单位法	Partially replace GB 15670-1995
GB/T 15670.5-2017	Toxicological test methods for pesticides registration—Part 5: Acute dermal toxicity test 农药登记毒理学试验方法第5部分：急性经皮毒性试验	Partially replace GB 15670-1995
GB/T 15670.6-2017	Toxicological test methods for pesticides registration—Part 6: Acute inhalation toxicity test 农药登记毒理学试验方法第6部分：急性吸入毒性试验	Partially replace GB 15670-1995
GB/T 15670.7-2017	Toxicological test methods for pesticides registration—Part 7: Dermal irritation/corrosion test 农药登记毒理学试验方法第7部分：皮肤刺激性/腐蚀性试验	Partially replace GB 15670-1995
GB/T 15670.8-2017	Toxicological test methods for pesticides registration—Part 8: Acute eye irritation/corrosion test 农药登记毒理学试验方法第8部分：急性眼刺激性/腐蚀性试验	Partially replace GB 15670-1995
GB/T 15670.9-2017	Toxicological test methods for pesticides registration—Part 9: Skin sensitisation test 农药登记毒理学试验方法第9部分：皮肤变态反应（致敏）试验	Partially replace GB 15670-1995
GB/T 15670.10-2017	Toxicological test methods for pesticides registration—Part 10: Short-term repeated dose 28-day oral toxicity study 农药登记毒理学试验方法第10部分：短期重复经口染毒(28天)毒性试验	Partially replace GB 15670-1995
GB/T 15670.11-2017	Toxicological test methods for pesticides registration—Part 11: Short-term repeated dose 28-day dermal toxicity study 农药登记毒理学试验方法第11部分：短期重复经皮染毒(28天)毒性试验	Partially replace GB 15670-1995
GB/T 15670.12-2017	Toxicological test methods for pesticides registration—Part 12: Short-term repeated dose 28-day inhalation toxicity study 农药登记毒理学试验方法第12部分：短期重复吸入染毒(28天)毒性试验	Partially replace GB 15670-1995
GB/T 15670.13-2017	Toxicological test methods for pesticides registration—Part 13: Subchronic toxicity study 农药登记毒理学试验方法第13部分：亚慢性毒性试验	Partially replace GB 15670-1995
GB/T 15670.14-2017	Toxicological test methods for pesticides registration—Part 14: Bacterial reverse mutation test 农药登记毒理学试验方法第14部分：细菌回复突变试验	Partially replace GB 15670-1995
GB/T 15670.15-2017	Toxicological test methods for pesticides registration—Part 15: In vivo mammalian bone marrow polychromatic erythrocyte micronucleus test 农药登记毒理学试验方法第15部分：体内哺乳动物骨髓嗜多染红细胞微核试验	Partially replace GB 15670-1995
GB/T 15670.16-2017	Toxicological test methods for pesticides registration—Part 16: In vivo mammalian bone marrow cell chromosome aberration test 农药登记毒理学试验方法第16部分：体内哺乳动物骨髓细胞染色体畸变试验	Partially replace GB 15670-1995
GB/T 15670.17-2017	Toxicological test methods for pesticides registration—Part 17: Mammalian spermatogonial/spermatocyte chromosome aberration test 农药登记毒理学试验方法第17部分：哺乳动物精原细胞/精母细胞染色体畸变试验	Partially replace GB 15670-1995
GB/T 15670.18-2017	Toxicological test methods for pesticides registration—Part 18: Rodent dominant lethal test 农药登记毒理学试验方法第18部分：啮齿类动物显性致死试验	Partially replace GB 15670-1995
GB/T 15670.19-2017	Toxicological test methods for pesticides registration—Part 19: In vitro mammalian cells chromosome aberration test 农药登记毒理学试验方法第19部分：体外哺乳动物细胞染色体畸变试验
GB/T 15670.20-2017	Toxicological test methods for pesticides registration—Part 20: In vitro mammalian cell gene mutation test 农药登记毒理学试验方法第20部分：体外哺乳动物细胞基因突变试验
GB/T 15670.21-2017	Toxicological test methods for pesticides registration—Part 21: Unscheduled DNA synthesis (UDS) test with mammalian liver cells in vivo 农药登记毒理学试验方法第21部分：体内哺乳动物肝细胞程序外DNA合成(UDS)试验
GB/T 15670.22-2017	Toxicological test methods for pesticides registration—Part 22: DNA damage and repair/unscheduled DNA synthesis in mammalian cells in vitro 农药登记毒理学试验方法第22部分：体外哺乳动物细胞DNA损害与修复/程序外DNA合成试验
GB/T 15670.23-2017	Toxicological test methods for pesticides registration—Part 23: Teratogenicity study 农药登记毒理学试验方法第23部分：致畸试验	Partially replace GB 15670-1995
GB/T 15670.24-2017	Toxicological test methods for pesticides registration—Part 24: Two-generation reproduction toxicity study 农药登记毒理学试验方法第24部分：两代繁殖毒性试验	Partially replace GB 15670-1995
GB/T 15670.25-2017	Toxicological test methods for pesticides registration—Part 25: Acute delayed neurotoxicity test 农药登记毒理学试验方法第25部分：急性迟发性神经毒性试验	Partially replace GB 15670-1995
GB/T 15670.26-2017	Toxicological test methods for pesticides registration—Part 26: Chronic toxicity study 农药登记毒理学试验方法第26部分：慢性毒性试验	Partially replace GB 15670-1995
GB/T 15670.27-2017	Toxicological test methods for pesticides registration—Part 27: Carcinogenicity study 农药登记毒理学试验方法第27部分：致癌试验	Partially replace GB 15670-1995
GB/T 15670.28-2017	Toxicological test methods for pesticides registration—Part 28: Combined chronic toxicity/carcinogenicity study 农药登记毒理学试验方法第28部分：慢性毒性与致癌合并试验	Partially replace GB 15670-1995
GB/T 15670.29-2017	Toxicological test methods for pesticides registration—Part 29: Metabolism and toxicokinetics study 农药登记毒理学试验方法第29部分：代谢和毒物动力学试验	Partially replace GB 15670-1995

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SAC's News Release(in Chinese)

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