On 20th November, the EU approved the active substances flumetralin, mandestrobin, and flupyradifurone as candidates for substitution, in accordance with Regulation （EC） No 1107/2009 of the European Parliament and of the Council concerning the placing of plant protection products on the market, and amending Commission Implementing Regulation （EU） No 540/2011. Additionally, the regulation reminds to concern the protection of pesticide operator and the potential risk towards environment and creatures.