Notes of 18th Conference of pesticide registration review committee

The 18^th pesticide registration committee conference has been held on Dec. 15^th of 2015 in Beijing. The conference reviewed pesticide products that applied for registration. The conference has been discussed the following topics:

Review opinions on pesticides that applied for pesticide registration
Toxic reviewing principle on relief of residual test of low toxic seed treatment products
Registration advice on 2,4-D butylate product
Registration advice on aluminium phosphide products
Registration advice on dicofol products

During the conference, the committee evaluated 23 kinds of pesticides, among which 12 pesticides were assessed for the first time, and 11 pesticides were reviewed. The evaluation covered 4 herbicides, 3 insecticides, 10 fungicides, 3 hygienic insecticides, 2 plant growth regulators and 1 raticide from 21 applicants with 44 products. After evaluation, the committee agreed to pass the formal registration application of 29 products covering 14 kinds of pesticide. Detailed pesticide information is as followed:

No.	Product Name	Application Scope	Applicant	Evaluation Comments
1	95% Zoxamide TM	/	America Gowan	Approve formal registration
	75% Zoxamide mancozeb WG	Cucumber (downy mildew)
2	97% Cholecalciferol TM	/	Zhejiang Garden Biochemical High-tech	Approve formal registration
	0.075% Cholecalciferol particles	Indoor (rat)
3	95% Acrinathrin TM	/	Jiangsu Youth Chemical	Approve formal registration
	0.4% Acrinathrin AE	Indoor (Mosquito, fly)
4	98% Dufulin TM	/	Guangxi Tianyuan Bio-chemical	Approve formal registration
	30% Dufulin WP	Tomato (virus disease), rice (black-streaked dwarf disease)
5	98% Thiencarbazone-methyl TM	/	Bayer CropScience	Approve formal registration
	97.2% Isoxvaflutole TM	/
	26% Thiencarbazone– isoxazole SC	Corn (annual weeds)
6	95% Oxathiapiprolin TM	/	Dupont	Approve formal registration
	10% Oxathiapiprolin OD	Tomato(late blight), cucumber(downy mildew), pepper (epidemic disease), grape(downy mildew), potato(late blight)
7	98.5% Metoxadiazonen TM	/	Jiangsu Youth Chemical.	Approve formal registration
	22% D-phenothrin- metoxadiazone FK	Indoor (mosquito, fly, flea, house dust mite)	Tianjin Earth Chemical
8	95.9% Sulfoxaflor TM	/	Dow AgroScience	1. Approve formal registration of 95.9% TM, 50% sulfoxaflor WG on cucumber, and 22% sulfoxaflor SC on rice 2. Since the dosage of residual test is different from dosage of pesticide efficacy test, committee disagree to approve 22% sulfoxaflor SC on cucumber
	50% Sulfoxaflor WG	Cotton (mired, bemisia tabaci)
	22% Sulfoxaflor SC	Rice(rice planthopper)
9	99.1% Dinotefuran TM	/	Mitsui Chemicals Agro	1. Approve formal registration of 99.1% dinotefuran TM and 20% dinotefuran SGX on cucumber 2. Since lacking of residual data of parent and metabolite on rice, committee disagree to approve 20% dinotefuran SGX on rice
	20% Dinotefuran SGX	Cucumber (protection of whitefly, thrips)
10	15% Tetramycin TM	/	Liaoning Wkioc Bioengineering	Approve formal registration
	0.3% Tetramycin AS	Wheat(powdery mildew, fusarium head blight), polar(canker)
11	98% Prochloraz copper TM	/	Jiangsu Huifeng Agrochemical	Approve formal registration
	50% Prochloraz copper SC	Apple tree (anthracnose)
12	98% Fluxapyroxad TM	/	BASF	1. Approve formal registration of 98% fluxapyroxad TM, 42.4% pyraclostrobin-fluxapyroxad SC on tomato (gray mold);12% fluxapyroxad-epoxiconazole EC on banana (leaf spot disease); 2. Since lacking of demonstration test report, committee disagree to approve registration of 42.4% pyraclostrobin–fluxapyroxad SC on tomato (leaf mold), strawberry (powdery mildew, gray mold), pepper (anthracnose), water melon (powdery mildew), cucumber (powdery mildew, gray mold), mango (anthracnose), potato (early blight), banana (scab); 3. Since lacking of demonstration test report, committee disagrees to approve registration of 12% fluxapyroxad-epoxiconazole EC on rice (banded sclerotial blight).
	42.4% Pyraclostrobin -fluxapyroxad SC	Tomato (gray mold),
	12% Fluxapyroxad-epoxiconazole EC	Banana (leaf spot disease)
13	100 Billion bacillus amyloliquefaciens TM	/	Shanxi Xiannong Technology	Approve formal registration
	100 Billion bacillus amyloliquefaciens WP	Rice(rice blast)

In addition, the committee disagreed to pass the formal registration application of 14 products covering 8 kinds of pesticides. For those has been refused for registration, applicants may submit supplementing documents based on committee’s review opinion and try a second time. In addition, the committee suggests applicants to submit opinion on whether hemin can be classified in pesticide management area for evaluation.

No.	Product Name	Application Scope	Applicant	Evaluation Comments
1	85% Prohexadione-calcium TM	/	Hubei Yizailing Agro Tech.	Mechanisms of action is unclear
1	5% Prohexadione-calcium PP	Rice(growth regulator)	Hubei Yizailing Agro Tech.	Mechanisms of action is unclear
2	2 Billion spore coniothyrium minitans WP	Rape(clerotiniose)	Wuxi Jiannong Bio-tech	1. Microbial pesticide should be clear with strain number, while this applicant has not provided complete strain number information, and the product’s English name is similar to another product; 2. Based on the evaluation of manufacturing process, this product may also produce TM, so the product should also register for TM.
3	96% Methiadinil TM	/	Lier Chemical	1. Action mechanism is unclear; 2. Lacking of at least two demonstration testing report of different environmental area; 3. Since the teratogenicity test results show that methiadinil would cause teratogenic effect on the skeleton of fetal rat, and chronic toxicity test shows that even low dose equals maximum no-effect dose, applicant should submit more documents to demonstrate that this pesticide has no health risk on human beings.
3	25% Methiadinil SC	Tabaco(virus disease)	Lier Chemical
4	95% Fenoxycarb TM	/	Jiangsu Changlong Chemical	1. Lacking of application report during temporary registration; 2. The residual document does not meet the requirement of “Pesticide Registration Residual Testing Standard” 3. oversea registration situation is unclear; 4. The TM shows medium toxicity on fleas, this is not qualified with exemption of environment testing for preparations.
4	5% Fenoxycarb DP	Grain(insects in grain storage)	Jiangsu Changlong Chemical
5	95% Flufenacet TM	/	Bayer CropScience	1. Lacking of application report during temporary registration; 2. Lacking of temporary registration demonstration test report.
	98% Flurtamone TM	/
	33% Flufenacet-diflufenican	Winter wheat (annual wheat)
6	50% Allicin TM	/	Chengdu New Sun CropScience	Lacking of residual report, the technical concentrate is classified as medium toxic substance, applicant should submit residual report for safety evaluation
6	5% Allicin ME	Cucumber(bacterial angular leaf spot disease), cabbage(soft rot)	Chengdu New Sun CropScience
7	90% Chlorempenthrin TM	/	Hebei Sannong Agrow Chemical	1. The chlorempenthrin TM is medium toxic substance that it cannot be used indoor; 2. Lacking of outdoor environmental document.
7	0.4% Chlorempenthrin SF	Indoor (fly)	Guanghan Erxian Mosquito
8	0.3% Hemin WP	Tomato, Potato(growth regulator)	Nantong Feitian Chemical Industrial	Hermin is currently not regulated by pesticide regulations, applicant should organize specialists to discuss whether hemin should be managed under pesticide area and submit supporting documents.

Also, the committee established a toxic judging prince on exemption of residual test of low toxic seed treatment. According to “Data Requirement on Pesticide Regulation”, normally, there is no residual testing requirements for low toxic seed treatment products. However, in China, the same pesticide products may have difference toxic grade, to regulate pesticide registration technical requirements, the committee came to an agreement that pesticide evaluation should consider the highest risk. It means that when the same pesticide with different toxic grade applying as seed treatment, the product should be classified as the highest toxic grade. And if there is technical material for seed treatment belongs to moderately toxic or higher toxic should conduct residual test.

During the conference, the committee made some suggestions on the management of 2,4-D butylate and aluminium phosphide based on the application supervision and risk assessment results. Application supervision and risk assessment results of 2,4-D butylate shows that:

2,4-D butylate is volatile that may cause phytotoxicity to registered plant and nearby plant
2,4-D butylate shows high toxicity to aquatic organism’s acute toxicity, and chronic toxicity leads to decrease of survival rate and reproductive capacity
disruption of endocrine to human being

The committee suggested not accepting or approving any field test or registration application for products with 2,4-D butylate, and stop renewal of registration. As for exportation registration, the committees have not come up with a final agreement. The supervision and risk assessment of aluminium phosphide indicates that when farmers use aluminium phosphide to prevent pest of grain storage, poison incident happens from time to time. As a result, committee suggests to strengthening the management of aluminium phosphide products. Firstly, product label should be upgraded.

Indicate that improper application may lead to danger
Clarify application notice and process
Advice to operate by professional
Mark with high-toxic signal

Secondly, aluminium phosphide must be packaged with double bags to make sure that user may not touch the aluminium phosphide directly. Thirdly, aluminium phosphide products sellers should warm consumers the operating process and emergency actions when sell products to consumers and commit real-name registration rules. Finally, to commit to the “Stockholm Convention on POPs”, the last dicofol production line has been closed in 2014 and there is no dicofol product manufacturing in China now. Committee decided that they would not accept and approve dicofol field test, pesticide registration, or renewal of registration. Registered certificate will all valid until 17^th May of 2016. And no more dicofol products can be used from 17^th May of 2018.

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