• Brazil is pushing forward new regulations for toxicological evaluation and classification of pesticides;

• Pesticides will be classified, labeled and packaged in accordance with GHS;

• Structure-activity relationship analysis will be widely adopted to reduce animal testing and identify regulatory endpoints;

On 3 Nov 2016, Brazil ANVISA hosted a public hearing regarding three daft rules on toxicological evaluation, labeling and toxicological ratings of pesticides and components (adjuvants). Currently, the evaluation and classification are made under ANVISA Ordinance 3 of 1992, which is now incompatible with the technical and scientific developments made over the last 3 decades since its implementation. The proposed replacement of Ordinance 3 and the release of the latest draft rules reflect the desire of Brazilian authorities to align its national standards with global best practices and the current state of the art. In addition to the new data requirements and criterion, the adoption of GHS is one of the major innovations in the new drafts.